Meg Myles was a standout actress known for her powerful presence in dramatic roles on the big screen. Early in her career, Meg Myles made a name for herself with memorable performances, starting with her role on the long-running CBS series The Edge of Night (1955–1985). Around the same time, she appeared in the gripping drama The Phenix City Story (1955), starring John McIntire, which helped solidify her reputation as a rising talent. As her career progressed, Meg Myles continued to take on compelling roles, including a part in the 1968 thriller Coogan’s Bluff.

She then joined the cast of the popular CBS soap opera Where the Heart Is (1969–1973), where Meg Myles further showcased her emotional depth and range. In 1971, she appeared in The Anderson Tapes, a crime drama that added another strong credit to her growing filmography. Though she took on fewer roles in later years, Meg Myles remained active in the industry, appearing in the ABC miniseries Seasonal Differences (1987–88).

Even decades after her early successes, Meg Myles continued to contribute to film, with a notable appearance in the 1997 indie drama Delinquent, co-starring Desmond Devenish. Throughout her career, Meg Myles demonstrated a quiet strength and versatility that left a lasting impression on audiences and critics alike.